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Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea

Title
Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea
Authors
Kim Y.Park S.K.Han W.Kim D.-H.Hong Y.-C.Ha E.H.Ahn S.-H.Noh D.-Y.Kang D.Yoo K.-Y.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2009
Journal Title
Cancer Epidemiology Biomarkers and Prevention
ISSN
1055-9965JCR Link
Citation
vol. 18, no. 2, pp. 508 - 515
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
High-density lipoprotein cholesterol (HDL-C) has been suggested to be associated with breast cancer. However, the roles of HDL-C and hypertriglyceridemia on breast cancer still have been controversial. The goal of this study was to investigate the association between HDL-C with breast cancer risk, stratifying by menopausal status, and body mass index. The hormonal receptor status of breast has been proposed to modify the effect of HDL-C on breast cancer. Multicenter hospital-based case-control study was conducted from November 2004 to December 2005 in Korea. After one to two individual matchings by age (±5 years) and menopausal status, 690 cases and 1,380 controls were included in the analysis. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by conditional, unconditional, and multinomial logistic regressions. Protective effect of HDL-C on breast cancer was only observed among premenopausal women with an OR (95% CI) of 0.49 (0.33-0.72) for HDL-C ≥60 versus <50 mg/dL (Ptrend < 0.01). Only nonobese premenopausal women had a significant decreased risk (OR, 0.34; 95% CI, 0.22-0.53). OR (95% CI) of low HDL-C (<50 mg/dL) and high triglyceride (TG; ≥150 mg/dL) category was 2.20 (1.32-3.67) on estrogen receptor-negative and progesterone receptor-negative breast cancer compared with high HDL-C (≥50 mg/dL) and low TG (<150 mg/dL) category. This study suggests that higher level of HDL-C may reduce breast cancer risk among premenopausal women. Estrogen receptor-negative and progesterone receptor-negative breast cancer was associated with dyslipidemia, which implicates that association among HDL-C, TG, and breast cancer may be modified by eceptor status. Copyright © 2009 American Association for Cancer Research.
DOI
10.1158/1055-9965.EPI-08-0133
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의학전문대학원 > 의학과 > Journal papers
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