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The effect of polymer composition on the gelation behavior of PLGA-g-PEG biodegradable thermoreversible gels

Title
The effect of polymer composition on the gelation behavior of PLGA-g-PEG biodegradable thermoreversible gels
Authors
Tarasevich B.J.Gutowska A.Li X.S.Jeong B.-M.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2009
Journal Title
Journal of Biomedical Materials Research - Part A
ISSN
1549-3296JCR Link
Citation
vol. 89, no. 1, pp. 248 - 254
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Graft copolymers consisting of a poly(D,L-lactic acid-co-glycolic acid) backbone grafted with polyethylene glycol side chains were synthesized and formed thermoreversible gels in aqueous solutions that exhibited solution behavior at low temperature and sol-to-gel transitions at higher temperature. The composition of the polymer and relative amounts of polylactic acid, glycolic acid, and ethylene glycol were varied by controlling the precursor concentrations and reaction temperature. The gelation temperature could be systematically tailored from 15 to 34°C by increasing the concentration of polyethylene glycol in the graft copolymer. The gelation temperature also depended on the polymer molecular weight and concentration. This work has importance for the development of water soluble gels with tailored compositions and gelation temperatures for use in tissue engineering and as injectable depots for drug delivery. © 2008 Wiley Periodicals, Inc.
DOI
10.1002/jbm.a.32025
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자연과학대학 > 화학·나노과학전공 > Journal papers
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