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Identification and characterization of a human CD5+ pre-naive B cell population

Title
Identification and characterization of a human CD5+ pre-naive B cell population
Authors
Lee J.Kuchen S.Fischer R.Chang S.Lipsky P.E.
Ewha Authors
이지수
SCOPUS Author ID
이지수scopus
Issue Date
2009
Journal Title
Journal of Immunology
ISSN
0022-1767JCR Link
Citation
vol. 182, no. 7, pp. 4116 - 4126
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB1 transporter compared with transitional and naive B cells. These pre-naive B cells account for a majority of circulating human CD5+ B cells. Importantly, CD5+ pre-naive B cells could be induced to differentiate into cells with a naive phenotype in vitro. CD5+ pre-naive B cells show only partial responses to BCR stimulation and CD40 ligation and undergo more spontaneous apoptosis and cell death than do naive B cells, whereas BAFF/BLyS (B cell-activating factor belonging to the TNF family) did not enhance their survival compared with naive B cells. In contrast, CD5+ pre-naive B cells carry out certain functions comparable to naive B cells, including the capacity to differentiate into plasma cells and the ability to function as APCs. Notably, an increased proportion of CD5+ pre-naive B cells were found in peripheral blood of patients with systemic lupus erythematosus. These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus.
DOI
10.4049/jimmunol.0803391
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의학전문대학원 > 의학과 > Journal papers
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