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Identification and characterization of a human CD5+ pre-naive B cell population
- Title
- Identification and characterization of a human CD5+ pre-naive B cell population
- Authors
- Lee J.; Kuchen S.; Fischer R.; Chang S.; Lipsky P.E.
- Ewha Authors
- 이지수
- SCOPUS Author ID
- 이지수
- Issue Date
- 2009
- Journal Title
- Journal of Immunology
- ISSN
- 0022-1767
- Citation
- Journal of Immunology vol. 182, no. 7, pp. 4116 - 4126
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB1 transporter compared with transitional and naive B cells. These pre-naive B cells account for a majority of circulating human CD5+ B cells. Importantly, CD5+ pre-naive B cells could be induced to differentiate into cells with a naive phenotype in vitro. CD5+ pre-naive B cells show only partial responses to BCR stimulation and CD40 ligation and undergo more spontaneous apoptosis and cell death than do naive B cells, whereas BAFF/BLyS (B cell-activating factor belonging to the TNF family) did not enhance their survival compared with naive B cells. In contrast, CD5+ pre-naive B cells carry out certain functions comparable to naive B cells, including the capacity to differentiate into plasma cells and the ability to function as APCs. Notably, an increased proportion of CD5+ pre-naive B cells were found in peripheral blood of patients with systemic lupus erythematosus. These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus.
- DOI
- 10.4049/jimmunol.0803391
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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