Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지수 | - |
dc.date.accessioned | 2016-10-20T02:10:33Z | - |
dc.date.available | 2016-10-20T02:10:33Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | OAK-5501 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232496 | - |
dc.description.abstract | We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB1 transporter compared with transitional and naive B cells. These pre-naive B cells account for a majority of circulating human CD5+ B cells. Importantly, CD5+ pre-naive B cells could be induced to differentiate into cells with a naive phenotype in vitro. CD5+ pre-naive B cells show only partial responses to BCR stimulation and CD40 ligation and undergo more spontaneous apoptosis and cell death than do naive B cells, whereas BAFF/BLyS (B cell-activating factor belonging to the TNF family) did not enhance their survival compared with naive B cells. In contrast, CD5+ pre-naive B cells carry out certain functions comparable to naive B cells, including the capacity to differentiate into plasma cells and the ability to function as APCs. Notably, an increased proportion of CD5+ pre-naive B cells were found in peripheral blood of patients with systemic lupus erythematosus. These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus. | - |
dc.language | English | - |
dc.title | Identification and characterization of a human CD5+ pre-naive B cell population | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 182 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4116 | - |
dc.relation.lastpage | 4126 | - |
dc.relation.journaltitle | Journal of Immunology | - |
dc.identifier.doi | 10.4049/jimmunol.0803391 | - |
dc.identifier.wosid | WOS:000264574600024 | - |
dc.identifier.scopusid | 2-s2.0-64249160172 | - |
dc.author.google | Lee J. | - |
dc.author.google | Kuchen S. | - |
dc.author.google | Fischer R. | - |
dc.author.google | Chang S. | - |
dc.author.google | Lipsky P.E. | - |
dc.contributor.scopusid | 이지수(14424388700) | - |
dc.date.modifydate | 20180329110821 | - |