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Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis
- Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis
- Park J.-H.; Kim D.-S.; Cho Y.-J.; Kim Y.-J.; Jeong S.-Y.; Lee S.-M.; Cho S.-J.; Yun C.-W.; Jo I.; Nam J.-H.
- Ewha Authors
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- vol. 27, no. 13, pp. 1974 - 1983
- SCI; SCIE; SCOPUS
- Coxsackievirus B3 (CVB3) is a common agent of viral myocarditis, a major cause of sudden cardiac death, and ultimately dilated cardiomyopathy. However, there is no vaccine in clinical use. In this study, we identified the conserved amino acid sequences in the C-terminal region of the VP2 of the coxsackievirus B group and some echoviruses. The mutant virus, YYFF, with phenylalanines substituted for two tyrosines in these conserved sequences was highly attenuated in vivo and could induce a high neutralizing antibody titer and a cytotoxic T-lymphocyte response against CVB3. Thereby, mutant-virus-immunized mice showed a 100% survival rate and protection against inflammation of the heart and pancreas after lethal dose challenge. Thus, this mutant virus is a good candidate for an attenuated CVB3 vaccine. © 2009 Elsevier Ltd. All rights reserved.
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