Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조인호 | * |
dc.date.accessioned | 2016-10-20T02:10:33Z | - |
dc.date.available | 2016-10-20T02:10:33Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0264-410X | * |
dc.identifier.other | OAK-5510 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232489 | - |
dc.description.abstract | Coxsackievirus B3 (CVB3) is a common agent of viral myocarditis, a major cause of sudden cardiac death, and ultimately dilated cardiomyopathy. However, there is no vaccine in clinical use. In this study, we identified the conserved amino acid sequences in the C-terminal region of the VP2 of the coxsackievirus B group and some echoviruses. The mutant virus, YYFF, with phenylalanines substituted for two tyrosines in these conserved sequences was highly attenuated in vivo and could induce a high neutralizing antibody titer and a cytotoxic T-lymphocyte response against CVB3. Thereby, mutant-virus-immunized mice showed a 100% survival rate and protection against inflammation of the heart and pancreas after lethal dose challenge. Thus, this mutant virus is a good candidate for an attenuated CVB3 vaccine. © 2009 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis | * |
dc.type | Article | * |
dc.relation.issue | 13 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1974 | * |
dc.relation.lastpage | 1983 | * |
dc.relation.journaltitle | Vaccine | * |
dc.identifier.doi | 10.1016/j.vaccine.2009.01.008 | * |
dc.identifier.wosid | WOS:000264727900014 | * |
dc.identifier.scopusid | 2-s2.0-61349151123 | * |
dc.author.google | Park J.-H. | * |
dc.author.google | Kim D.-S. | * |
dc.author.google | Cho Y.-J. | * |
dc.author.google | Kim Y.-J. | * |
dc.author.google | Jeong S.-Y. | * |
dc.author.google | Lee S.-M. | * |
dc.author.google | Cho S.-J. | * |
dc.author.google | Yun C.-W. | * |
dc.author.google | Jo I. | * |
dc.author.google | Nam J.-H. | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.date.modifydate | 20240123112949 | * |