Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-10-20T02:10:30Z | - |
dc.date.available | 2016-10-20T02:10:30Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-5541 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232470 | - |
dc.description.abstract | Benz[b]oxepines 4a-g and 12-oxobenzo[c]phenanthridines 5a-d were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular radical cyclization reaction. Radical cyclization of O-vinyl compounds preferentially led to the 7-endo-trig cyclization pathway to the benz[b]oxepines and 12-oxobenzo[c]phenanthridines through 6-exo-trig path as minor products. Among the synthesized compounds, benz[b]oxepine derivative 4e exhibited potent in vitro cytotoxicity against three different tumor cell lines, as well as topoisomerase 1 inhibitory activity. A Surflex-Dock docking study was performed to clarify the topoisomerase 1 activity of 4e. © 2009 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2444 | * |
dc.relation.lastpage | 2447 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2009.03.058 | * |
dc.identifier.wosid | WOS:000265137100014 | * |
dc.identifier.scopusid | 2-s2.0-64249113960 | * |
dc.author.google | Lee S.-H. | * |
dc.author.google | Van H.T.M. | * |
dc.author.google | Yang S.H. | * |
dc.author.google | Lee K.-T. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Cho W.-J. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |