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An aniline bearing hemicyanine derivative serves as a mitochondria selective probe

Title
An aniline bearing hemicyanine derivative serves as a mitochondria selective probe
Authors
Lee D.Jung M.-K.Yin J.Kim G.Pack C.-G.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2017
Journal Title
Dyes and Pigments
ISSN
0143-7208JCR Link
Citation
vol. 136, pp. 467 - 472
Keywords
Fluorescent probeFluorescent sensorMitochondria selective probeMitochondria staining probe
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito. © 2016 Elsevier Ltd
DOI
10.1016/j.dyepig.2016.09.010
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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