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An aniline bearing hemicyanine derivative serves as a mitochondria selective probe
- An aniline bearing hemicyanine derivative serves as a mitochondria selective probe
- Lee D.; Jung M.-K.; Yin J.; Kim G.; Pack C.-G.; Yoon J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Dyes and Pigments
- vol. 136, pp. 467 - 472
- Fluorescent probe; Fluorescent sensor; Mitochondria selective probe; Mitochondria staining probe
- Elsevier Ltd
- SCI; SCIE; SCOPUS
- Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito. © 2016 Elsevier Ltd
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- 자연과학대학 > 화학·나노과학전공 > Journal papers
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