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Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue

Title
Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue
Authors
Park, Ye SeulUddin, Md JamalPiao, LingjuanHwang, InahLee, Jung HwaHa, Hunjoo
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2016
Journal Title
MEDIATORS OF INFLAMMATION
ISSN
0962-9351JCR Link1466-1861JCR Link
Publisher
HINDAWI PUBLISHING CORP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Macrophages are important components of adipose tissue inflammation, which results in metabolic diseases such as insulin resistance. Notably, obesity induces a proinflammatory phenotypic switch in adipose tissue macrophages, and oxidative stress facilitates this switch. Thus, we examined the role of endogenous catalase, a key regulator of oxidative stress, in the activity of adipose tissue macrophages in obese mice. Catalase knockout (CKO) exacerbated insulin resistance, amplified oxidative stress, and accelerated macrophage infiltration into epididymal white adipose tissue in mice on normal or high-fat diet. Interestingly, catalase deficiency also enhanced classical macrophage activation (M1) and inflammation but suppressed alternative activation (M2) regardless of diet. Similarly, pharmacological inhibition of catalase activity using 3-aminotriazole induced the same phenotypic switch and inflammatory response in RAW264.7 macrophages. Finally, the same phenotypic switch and inflammatory responses were observed in primary bone marrow-derived macrophages from CKO mice. Taken together, the data indicate that endogenous catalase regulates the polarization of adipose tissue macrophages and thereby inhibits inflammation and insulin resistance.
DOI
10.1155/2016/8675905
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약학대학 > 약학과 > Journal papers
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