Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2016-09-21T01:09:16Z | - |
dc.date.available | 2016-09-21T01:09:16Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0019-9567 | * |
dc.identifier.issn | 1098-5522 | * |
dc.identifier.other | OAK-19291 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232251 | - |
dc.description.abstract | The Bacteroides fragilis enterotoxin (BFT), a virulence factor of enterotoxigenic B. fragilis (ETBF), interacts with intestinal epithelial cells and can provoke signals that induce mucosal inflammation. Although expression of heme oxygenase-1 (HO-1) is associated with regulation of inflammatory responses, little is known about HO-1 induction in ETBF infection. This study was conducted to investigate the effect of BFT on HO-1 expression in intestinal epithelial cells. Stimulation of intestinal epithelial cells with BFT resulted in upregulated expression of HO-1. BFT activated transcription factors such as NF-kappa B, AP-1, and Nrf2 in intestinal epithelial cells. Upregulation of HO-1 in intestinal epithelial cells was dependent on activated I kappa B kinase (IKK)-NF-kappa B signals. However, suppression of Nrf2 or AP-1 signals in intestinal epithelial cells did not result in significant attenuation of BFT-induced HO-1 expression. HO-1 induction via IKK-NF-kappa B in intestinal epithelial cells was regulated by p38 mitogen-activated protein kinases (MAPKs). Furthermore, suppression of HO-1 activity led to increased apoptosis in BFT-stimulated epithelial cells. These results suggest that a signaling pathway involving p38 MAPK-IKK-NF-kappa B in intestinal epithelial cells is required for HO-1 induction during exposure to BFT. Following this induction, increased HO-1 expression may regulate the apoptotic process in responses to BFT stimulation. | * |
dc.language | English | * |
dc.publisher | AMER SOC MICROBIOLOGY | * |
dc.title | Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-kappa B-Dependent Pathway, Leading to Modulation of Apoptosis | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 84 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2541 | * |
dc.relation.lastpage | 2554 | * |
dc.relation.journaltitle | INFECTION AND IMMUNITY | * |
dc.identifier.doi | 10.1128/IAI.00191-16 | * |
dc.identifier.wosid | WOS:000382320300014 | * |
dc.identifier.scopusid | 2-s2.0-84984852086 | * |
dc.author.google | Ko, Su Hyuk | * |
dc.author.google | Rho, Da Jeong | * |
dc.author.google | Jeon, Jong Ik | * |
dc.author.google | Kim, Young-Jeon | * |
dc.author.google | Woo, Hyun Ae | * |
dc.author.google | Lee, Yun Kyung | * |
dc.author.google | Kim, Jung Mogg | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240215164922 | * |