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Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature
- Title
- Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature
- Authors
- Jung, Seo-Hee; Sung, Dan-Bi; Park, Cho-Hee; Kim, Won-Suk
- Ewha Authors
- 김원석
- SCOPUS Author ID
- 김원석
- Issue Date
- 2016
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- ISSN
- 0022-3263
- Citation
- JOURNAL OF ORGANIC CHEMISTRY vol. 81, no. 17, pp. 7717 - 7724
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.
- DOI
- 10.1021/acs.joc.6b01415
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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