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Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature
- Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature
- Jung, Seo-Hee; Sung, Dan-Bi; Park, Cho-Hee; Kim, Won-Suk
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- JOURNAL OF ORGANIC CHEMISTRY vol. 81, no. 17, pp. 7717 - 7724
- AMER CHEMICAL SOC
- SCI; SCIE; SCOPUS
- Document Type
- A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.
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