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Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature

Title
Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature
Authors
Jung, Seo-HeeSung, Dan-BiPark, Cho-HeeKim, Won-Suk
Ewha Authors
김원석
SCOPUS Author ID
김원석scopus
Issue Date
2016
Journal Title
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263JCR Link
Citation
vol. 81, no. 17, pp. 7717 - 7724
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.
DOI
10.1021/acs.joc.6b01415
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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