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1950MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice

Title
1950MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice
Authors
Son, YeonghoonJeong, Ye JiKwon, Jong HwaChoi, Hyung-DoPack, Jeong-KiKim, NamLee, Yun-SilLee, Hae-June
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2016
Journal Title
BIOELECTROMAGNETICS
ISSN
0197-8462JCR Link1521-186XJCR Link
Citation
vol. 37, no. 6, pp. 391 - 399
Keywords
Alzheimer's disease mice-amyloidmemory impairmentRF-EMFhippocampus
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The increased use of mobile phones has generated public concern about the impact of radiofrequency electromagnetic fields (RF-EMF) on health. In the present study, we investigated whether RF-EMFs induce molecular changes in amyloid precursor protein (APP) processing and amyloid beta (A)-related memory impairment in the 5xFAD mouse, which is a widely used amyloid animal model. The 5xFAD mice at the age of 1.5 months were assigned to two groups (RF-EMF- and sham-exposed groups, eight mice per group). The RF-EMF group was placed in a reverberation chamber and exposed to 1950MHz electromagnetic fields for 3 months (SAR 5W/kg, 2h/day, 5 days/week). The Y-maze, Morris water maze, and novel object recognition memory test were used to evaluate spatial and non-spatial memory following 3-month RF-EMF exposure. Furthermore, A deposition and APP and carboxyl-terminal fragment (CTF) levels were evaluated in the hippocampus and cortex of 5xFAD mice, and plasma levels of A peptides were also investigated. In behavioral tests, mice that were exposed to RF-EMF for 3 months did not exhibit differences in spatial and non-spatial memory compared to the sham-exposed group, and no apparent change was evident in locomotor activity. Consistent with behavioral data, RF-EMF did not alter APP and CTF levels or A deposition in the brains of the 5xFAD mice. These findings indicate that 3-month RF-EMF exposure did not affect A-related memory impairment or A accumulation in the 5xFAD Alzheimer's disease model. Bioelectromagnetics. 37:391-399, 2016. (c) 2016 The Authors Bioelectromagnetics published by Wiley Periodicals, Inc. on behalf of Bioelectromagnetics Society.
DOI
10.1002/bem.21992
Appears in Collections:
약학대학 > 약학과 > Journal papers
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