Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | * |
dc.contributor.author | 이상국 | * |
dc.contributor.author | 최선 | * |
dc.contributor.author | 최원준 | * |
dc.date.accessioned | 2016-08-29T11:08:02Z | - |
dc.date.available | 2016-08-29T11:08:02Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0022-2623 | * |
dc.identifier.other | OAK-5869 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232060 | - |
dc.description.abstract | The first synthesis of 2′-deoxy-2′-fluoro-4′- selenoarabinofuranosyl pyrimidines as potent anticancer agents was accomplished using the DAST fluorination as a key step. It was first revealed that selenium atom participated in the DAST fluorination of 4′-selenonucleosides and that conformational bias induced by bulky selenium acted as a decisive factor in the DAST fluorination. Among compounds tested, 2′-F-4′-seleno-ara-C (4a) exhibited highly potent anticancer activity in all cancer cell lines tested and was more potent than ara-C (1). © 2009 American Chemical Society. | * |
dc.language | English | * |
dc.title | Discovery of a new template for anticancer agents: 2′-deoxy-2′- fluoro-4′-selenoarabinofuranosyl-cytosine (2′-F-4′-seleno-ara- C) | * |
dc.type | Article | * |
dc.relation.issue | 17 | * |
dc.relation.volume | 52 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5303 | * |
dc.relation.lastpage | 5306 | * |
dc.relation.journaltitle | Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1021/jm900852b | * |
dc.identifier.wosid | WOS:000269655500004 | * |
dc.identifier.scopusid | 2-s2.0-69949094546 | * |
dc.author.google | Lak S.J. | * |
dc.author.google | Tosh D.K. | * |
dc.author.google | Won J.C. | * |
dc.author.google | Sang K.L. | * |
dc.author.google | Kang Y.-J. | * |
dc.author.google | Choi S. | * |
dc.author.google | Jin H.L. | * |
dc.author.google | Lee H. | * |
dc.author.google | Hyuk W.L. | * |
dc.author.google | Hea O.K. | * |
dc.contributor.scopusid | 정낙신(16028528200) | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 최선(8659831000) | * |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | * |
dc.date.modifydate | 20240305081003 | * |