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PVPylated poly(alanine) as a new thermogelling polymer

Title
PVPylated poly(alanine) as a new thermogelling polymer
Authors
Han J.O.Joo M.K.Jang J.H.Park M.H.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2009
Journal Title
Macromolecules
ISSN
0024-9297JCR Link
Citation
vol. 42, no. 17, pp. 6710 - 6715
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to investigate poly(N-vinyl pyrrolidone) as an alternative to polyethylene glycol) in preparing a biomedical polymer, we synthesized a series of reverse thermogelling poly(N-vinyl pyrrolidone-b-alanine) (PVP-PA). The amphiphilic polymers consisting of the hydrophilic PVP block and the hydrophobic PA block formed micelles in water and the micelles aggregated as the temperature increased. FTIR spectroscopy, circular dichrosim spectroscopy, and 13C NMR spectroscopy showed that the aggregation behavior accompanied a change in PA conformation as well as a decrease in the molecular motion of PVP-PA. The sol-to-gel transition temperature decreased as the PA block length increased, PVP block length decreased, and L-alanine/DL-alanine ratio of PA increased. This paper suggests that PVP can be a promising alternative to poly(ethylene glycol) in designing a reverse thermogelling biomaterial. © 2009 American Chemical Society.
DOI
10.1021/ma901089s
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자연과학대학 > 화학·나노과학전공 > Journal papers
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