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PKA-Mediated stabilization of FoxH1 negatively regulates ERα activity

Title
PKA-Mediated stabilization of FoxH1 negatively regulates ERα activity
Authors
Yum J.Jeong H.M.Kim S.Seo J.W.Han Y.Lee K.-Y.Yeo C.-Y.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2009
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 28, no. 1, pp. 67 - 71
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Estrogen receptor α (ERα) mediates the mitogenic effects of estrogen. ERα signaling regulates the normal growth and differentiation of mammary tissue, but uncontrolled ERα activation increases the risk to breast cancer. Estrogen binding induces ligand-dependent ERα activation, thereby facilitating ERα dimerization, promoter binding and coactivator recruitment. ERα can also be activated in a ligand-independent manner by many signaling pathways, including protein kinase A (PKA) signaling. However, in several ERα-positive breast cancer cells, PKA inhibits estrogen-dependent cell growth. FoxH1 represses the transcriptional activities of estrogen receptors and androgen receptors (AR). Interestingly, FoxH1 has been found to inhibit the PKA-induced and ligand-induced activation of AR. In the present study, we examined the effects of PKA activation on the ability of FoxH1 to represses ERα transcriptional activity. We found that PKA increases the protein stability of FoxH1, and that FoxH1 inhibits PKA-induced and estradiol-induced activation of an estrogen response element (ERE). Furthermore, in MCF7 cells, FoxH1 knockdown increased the PKA-induced and estradiol-induced activation of the ERE. These results suggest that PKA can negatively regulate ERα, at least in part, through FoxH1. © The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2009.
DOI
10.1007/s10059-009-0099-7
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자연과학대학 > 생명과학전공 > Journal papers
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