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The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles

Title
The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
Authors
Cho M.Cho W.-S.Choi M.Kim S.J.Han B.S.Kim S.H.Kim H.O.Sheen Y.Y.Jeong J.
Ewha Authors
신윤용
SCOPUS Author ID
신윤용scopus
Issue Date
2009
Journal Title
Toxicology Letters
ISSN
0378-4274JCR Link
Citation
vol. 189, no. 3, pp. 177 - 183
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Many approaches for the application of nano-sized particles to the human body as nanotechnology have been recently developed. The size of nanoparticles is related to their useful character and also plays a key role in toxicity. Since this surface area can interact with biological components of cells, nanoparticles can be more reactive in than larger particles. In the present study, a fluorescence dye-labeled 50, 100 and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo. Incidence and severity of inflammatory response was transiently increased with injection of 200 and 100 nm silica nanoparticles within 12 h. But there was no significant response related to injection of 50 nm particles. The silica particles of 50, 100 and 200 nm were cleared via urine and bile. The 50 nm silica nanoparticles cleared to urine and bile than 100 nm and particles of 200 nm existed at lower concentration than other two smaller particles in urine and feces. Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection. © 2009 Elsevier Ireland Ltd.
DOI
10.1016/j.toxlet.2009.04.017
Appears in Collections:
약학대학 > 약학과 > Journal papers
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