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Bombyx mori transferrin: Genomic structure, expression and antimicrobial activity of recombinant protein

Title
Bombyx mori transferrin: Genomic structure, expression and antimicrobial activity of recombinant protein
Authors
Yun E.-Y.Lee J.-K.Kwon O.-Y.Hwang J.-S.Kim I.Kang S.-W.Lee W.-J.Ding J.L.You K.-H.Goo T.-W.
Ewha Authors
이원재
Issue Date
2009
Journal Title
Developmental and Comparative Immunology
ISSN
0145-305XJCR Link
Citation
Developmental and Comparative Immunology vol. 33, no. 10, pp. 1064 - 1069
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Transferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates. Although transferrin has been suggested to play a role in innate immunity, its immunological function during infection has not been characterized. In this study, we identified and characterized Bombyx mori transferrin (BmTf). The promoter region of BmTf has numerous putative NF-κB binding sites, suggesting its possible function in innate immunity. Analysis of BmTf gene expression shows that it is highly inducible in response to a wide variety of pathogens including bacteria, fungus, and viruses. Recombinant BmTf protein produced in a baculovirus system exhibits iron binding capacity and antibacterial activity against various Gram-positive and -negative bacteria. Taken together, our results indicate that BmTf is an inducible immune effector molecule that may play an important role in pathogen clearance of insect innate immunity. © 2009 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.dci.2009.05.008
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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