View : 87 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author이원재-
dc.date.accessioned2017-08-28T20:06:26Z-
dc.date.available2017-08-28T20:06:26Z-
dc.date.issued2009-
dc.identifier.issn0145-305X-
dc.identifier.otherOAK-5835-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/232035-
dc.description.abstractTransferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates. Although transferrin has been suggested to play a role in innate immunity, its immunological function during infection has not been characterized. In this study, we identified and characterized Bombyx mori transferrin (BmTf). The promoter region of BmTf has numerous putative NF-κB binding sites, suggesting its possible function in innate immunity. Analysis of BmTf gene expression shows that it is highly inducible in response to a wide variety of pathogens including bacteria, fungus, and viruses. Recombinant BmTf protein produced in a baculovirus system exhibits iron binding capacity and antibacterial activity against various Gram-positive and -negative bacteria. Taken together, our results indicate that BmTf is an inducible immune effector molecule that may play an important role in pathogen clearance of insect innate immunity. © 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleBombyx mori transferrin: Genomic structure, expression and antimicrobial activity of recombinant protein-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume33-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1064-
dc.relation.lastpage1069-
dc.relation.journaltitleDevelopmental and Comparative Immunology-
dc.identifier.doi10.1016/j.dci.2009.05.008-
dc.identifier.wosidWOS:000268952800003-
dc.identifier.scopusid2-s2.0-67650222174-
dc.author.googleYun E.-Y.-
dc.author.googleLee J.-K.-
dc.author.googleKwon O.-Y.-
dc.author.googleHwang J.-S.-
dc.author.googleKim I.-
dc.author.googleKang S.-W.-
dc.author.googleLee W.-J.-
dc.author.googleDing J.L.-
dc.author.googleYou K.-H.-
dc.author.googleGoo T.-W.-
dc.date.modifydate20160829090609-
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE