Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-29T11:08:08Z | - |
dc.date.available | 2016-08-29T11:08:08Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1567-5769 | * |
dc.identifier.other | OAK-5786 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232011 | - |
dc.description.abstract | Several sesquiterpene lactones that have been isolated from medicinal plants are known to have many pharmacological activities. In this study, we investigated the anti-inflammatory effects of zedoarondiol, a sesquiterpene lactone isolated from the rhizoma of Curcuma heyneana, in lipopolysaccharide (LPS)-stimulated macrophage cells. Zedoarondiol dose-dependently inhibited LPS-stimulated nitric oxide (NO), prostaglandin E 2 (PGE 2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells. Consistent with these findings, in RAW 264.7 cells, zedoarondiol suppressed the LPS-stimulated protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the mRNA expressions of iNOS, COX-2, TNF-α, IL-6, and IL-1β in a concentration-dependent manner. Moreover, molecular data revealed that zedoarondiol inhibited LPS-stimulated DNA binding activity and the transcription activity of nuclear factor-kappa B (NF-κB), and this effect was accompanied by decreases in the degradation and phosphorylation of inhibitory κB (IκB)-α, and in the subsequent blocking of NF-κB translocations to the nucleus. Furthermore, zedoarondiol attenuated the phosphorylations of IκB kinase (IKK), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (p38), and c-Jun N-terminal kinase (JNK) in LPS-stimulated RAW 264.7 cells. Taken together, the findings of the present study indicate that zedoarondiol inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-κB pathway. These relations reveal, in part, the mechanism underlying the anti-inflammatory properties of zedoarondiol. © 2009. | * |
dc.language | English | * |
dc.title | Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-κB pathway in LPS-stimulated murine macrophages | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1049 | * |
dc.relation.lastpage | 1057 | * |
dc.relation.journaltitle | International Immunopharmacology | * |
dc.identifier.doi | 10.1016/j.intimp.2009.04.012 | * |
dc.identifier.wosid | WOS:000268360800004 | * |
dc.identifier.scopusid | 2-s2.0-67649584085 | * |
dc.author.google | Cho W. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Kang H.-J. | * |
dc.author.google | Windono T. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee K.-T. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |