Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-29T11:08:00Z | - |
dc.date.available | 2016-08-29T11:08:00Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.other | OAK-5781 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232007 | - |
dc.description.abstract | Cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents used in the treatment of a variety of human solid tumors. However, its clinical use is rather limited as a result of severe nephrotoxicity. The principal objective of this study was to evaluate the protective effect of Prunus persica flesh extract (PPFE) against cisplatin-induced nephrotoxicity in animal models, and whether its use influences the therapeutic efficacy of cisplatin. The administration of PPFE alone significantly inhibited the growth of CT-26 colon carcinoma xenografted onto mice without adverse effects. The combination of PPFE and cisplatin enhanced the inhibitory effect of cisplatin against tumor growth. In a xenograft model involving the repeated administration of low-dose cisplatin for 15 days, and in an acute toxicity model involving a single administration of high-dose cisplatin over a 16 h period, the administration of PPFE in combination with and prior to the cisplatin injection reversed the cisplatin-induced reduction in the kidney weight. PPFE blocked the increases in the serum blood urea nitrogen and creatinine levels associated with the kidney damage. Moreover, the administration of PPFE induced a significant reduction in cisplatin-induced oxidative stress. These results indicate that PPFE may promote the therapeutic efficacy of cisplatin therapy, while attenuating its inherent nephrotoxicity. Copyright © 2009 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.title | Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 999 | - |
dc.relation.lastpage | 1005 | - |
dc.relation.journaltitle | Phytotherapy Research | - |
dc.identifier.doi | 10.1002/ptr.2740 | - |
dc.identifier.wosid | WOS:000268304700018 | - |
dc.identifier.scopusid | 2-s2.0-67650120047 | - |
dc.author.google | Chang K.L. | - |
dc.author.google | Park K.-K. | - |
dc.author.google | Hwang J.-K. | - |
dc.author.google | Sang K.L. | - |
dc.author.google | Chung W.-Y. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |