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Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27Kip1 expression

Title
Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27Kip1 expression
Authors
Chung J.S.Lee S.B.Park S.H.Kang S.T.Na A.R.Chang T.-S.Kim H.J.Yoo Y.D.
Ewha Authors
창동신
SCOPUS Author ID
창동신scopus
Issue Date
2009
Journal Title
Free Radical Research
ISSN
1071-5762JCR Link
Citation
vol. 43, no. 8, pp. 729 - 737
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Reactive oxygen species (ROS) steady-state levels are required for entry into the S phase of the cell cycle in normal cells, as well as in tumour cells. However, the contribution of mitochondrial ROS to normal cell proliferation has not been well investigated thus far. A previous report showed that Romo1 was responsible for the high ROS levels in tumour cells. Here, we show that endogenous ROS generated by Romo1 are indispensable for cell cycle transition from G1 to S phase in normal WI-38 human lung fibroblasts. The ROS level in these cells was down-regulated by Romo1 knockdown, resulting in cell cycle arrest in the G1 phase. This arrest was associated with an increase in the level of p27Kip1. These results demonstrate that mitochondrial ROS generated by Romo1 expression is required for normal cell proliferation and it is suggested that Romo1 plays an important role in redox signalling during normal cell proliferation.
DOI
10.1080/10715760903038432
Appears in Collections:
약학대학 > 약학과 > Journal papers
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