Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-29T11:08:34Z | - |
dc.date.available | 2016-08-29T11:08:34Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1567-5769 | * |
dc.identifier.other | OAK-5726 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231971 | - |
dc.description.abstract | In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on the regulation of NO production. 5-Hydroxyzerumbone inhibited the expressions of iNOS mRNA and protein in a concentration-dependent manner. Treatment with 5-hydroxyzerumbone also induced the expression of heme oxygenase-1 (HO-1) in macrophage cells. In addition, 5-hydroxyzerumbone inhibited LPS-induced transcriptional activation of NF-κB, indicating that regulation of NF-κB activity might be involved in the inhibition of NO production by 5-hydroxyzerumbone. 5-Hydroxyzerumbone, however, did not affect the degradation of IκB-α and the activation of p38 and ERK in LPS-treated cells. Taken together, these results suggest that down-regulation of LPS-induced NO production by 5-hydroxyzerumbone is mediated by the suppression of iNOS expression through the modulation of NF-κB activation and HO-1 induction in macrophage cells. © 2009 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells | * |
dc.type | Article | * |
dc.relation.issue | 41463 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 844 | * |
dc.relation.lastpage | 849 | * |
dc.relation.journaltitle | International Immunopharmacology | * |
dc.identifier.doi | 10.1016/j.intimp.2009.03.005 | * |
dc.identifier.wosid | WOS:000267444800007 | * |
dc.identifier.scopusid | 2-s2.0-67349280833 | * |
dc.author.google | Min H.-Y. | * |
dc.author.google | Kim M.S. | * |
dc.author.google | Jang D.S. | * |
dc.author.google | Park E.-J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee S.K. | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |