Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-29T11:08:49Z | - |
dc.date.available | 2016-08-29T11:08:49Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0168-8278 | * |
dc.identifier.other | OAK-5674 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231953 | - |
dc.description.abstract | Background/Aims: Oxidative stress via generation of reactive oxygen species is suggested to be the major mechanism of alcohol-induced liver injury. We investigated the effects of glutathione peroxidase-1 and catalase double deficiency (Gpx-1 -/-/Cat -/-) on liver injury and changes in the sulfur amino acid metabolism induced by binge ethanol administration. Methods: Ethanol (5 g/kg) was administered orally to the wild-type and the Gpx-1 -/-/Cat -/- mice every 12 h for a total of three doses. Mice were sacrificed 6 h after the final dose. Results: The Gpx-1/Cat deficiency alone increased malondialdehyde levels in liver significantly. Hepatic methionine adenosyltransferase (MAT) activity and S-adenosylmethionine levels were decreased, however, glutathione contents were not changed. Ethanol administration to the Gpx-1 -/-/Cat -/- mice increased the elevation of serum alanine aminotransferase activity, plasma homocysteine levels, hepatic fat accumulation and lipid peroxidation compared with the wild-type animals challenged with ethanol. Also the reduction of MAT activity and S-adenosylmethionine levels was enhanced, but MATI/III expression was increased significantly. Conclusions: The results indicate that Gpx-1 and Cat have critical roles in the protection of liver against binge ethanol exposure. Augmentation of ethanol-induced oxidative stress may be responsible for the impairment of the transsulfuration reactions and the aggravation of acute liver injury in the Gpx-1 -/-/Cat -/- mice. © 2009 European Association for the Study of the Liver. | * |
dc.language | English | * |
dc.title | Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 50 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1184 | * |
dc.relation.lastpage | 1191 | * |
dc.relation.journaltitle | Journal of Hepatology | * |
dc.identifier.doi | 10.1016/j.jhep.2009.01.030 | * |
dc.identifier.wosid | WOS:000266739600013 | * |
dc.identifier.scopusid | 2-s2.0-67349277157 | * |
dc.author.google | Kim S.J. | * |
dc.author.google | Lee J.W. | * |
dc.author.google | Jung Y.S. | * |
dc.author.google | Kwon D.Y. | * |
dc.author.google | Park H.K. | * |
dc.author.google | Ryu C.S. | * |
dc.author.google | Kim S.K. | * |
dc.author.google | Oh G.T. | * |
dc.author.google | Kim Y.C. | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |