Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-29T11:08:57Z | - |
dc.date.available | 2016-08-29T11:08:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | OAK-5568 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231908 | - |
dc.description.abstract | Honokiol is a naturally occurring neolignan abundant in Magnoliae Cortex and has showed anti-proliferative and pro-apoptotic effects in a wide range of human cancer cells. However, the molecular mechanisms on the anti-proliferative activity in cancer cells have been poorly elucidated. In this study, we evaluated the growth inhibitory activity of honokiol in cultured estrogen receptor (ER)-negative MDA-MB-231 human breast cancer cells. Honokiol exerted anti-proliferative activity with the cell cycle arrest at the G0/G1 phase and sequential induction of apoptotic cell death in a concentration-dependent manner. The honokiol-induced cell cycle arrest was well correlated with the suppressive expression of CDK4, cyclin D1, CDK2, cyclin E, c-Myc, and phosphorylated retinoblastoma protein (pRb) at Ser780. Apoptosis caused by honokiol was also concomitant with the cleavage of caspases (caspase-3, -8, and -9) and Bid along with the suppressive expression of Bcl-2, but it was independent on the expression of Bax and p53. In addition, honokiol-treated cells exhibited the cleavage of poly (ADP-ribose) polymerase (PARP) and DNA fragmentation. In the analysis of signal transduction pathway, honokiol down-regulated the expression and phosphorylation of c-Src, epidermal growth factor receptor (EGFR), and Akt, and consequently led to the inactivation of mTOR and its downstream signal molecules including 4E-binding protein (4E-BP) and p70 S6 kinase. These findings suggest that honokiol-mediated inhibitory activity of cancer cell growth might be related with the cell cycle arrest and induction of apoptosis via modulating signal transduction pathways. © 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 277 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 133 | - |
dc.relation.lastpage | 140 | - |
dc.relation.journaltitle | Cancer Letters | - |
dc.identifier.doi | 10.1016/j.canlet.2008.11.029 | - |
dc.identifier.wosid | WOS:000265475600003 | - |
dc.identifier.scopusid | 2-s2.0-62749139619 | - |
dc.author.google | Park E.-J. | - |
dc.author.google | Min H.-Y. | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Hong J.-Y. | - |
dc.author.google | Kang Y.-J. | - |
dc.author.google | Hung T.M. | - |
dc.author.google | Youn U.J. | - |
dc.author.google | Kim Y.S. | - |
dc.author.google | Bae K. | - |
dc.author.google | Kang S.S. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |