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End groups adjusting the molecular nano-assembly pattern and thermal gelation of polypeptide block copolymer aqueous solution

Title
End groups adjusting the molecular nano-assembly pattern and thermal gelation of polypeptide block copolymer aqueous solution
Authors
Kim J.Y.Park M.H.Joo M.K.Lee S.Y.Jeong B.
Ewha Authors
이수영정병문
SCOPUS Author ID
이수영scopus; 정병문scopus
Issue Date
2009
Journal Title
Macromolecules
ISSN
0024-9297JCR Link
Citation
vol. 42, no. 8, pp. 3147 - 3151
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We are reporting end-capping of the amino groups of a polypeptide block copolymer by hydrophobic alkyl groups including methyl, ethyl, and propyl group. The end-capped polymer aqueous solution undergoes sol-to-gel transition as the temperature increases in a physiologically important temperature range of 10-40 °C, whereas the unmodified polymer does not show the transition. In addition, secondary structure of the polypeptide changed from random coils to /3-sheets and the assembled pattern changed from spherical micelles into cylindrical nanofibrous structures in water by the hydrophobic end-capping of the polymer. The enhanced hydrophobic interactions by the alkyl end groups recruit the hydrophobic polypeptides in a more organized way to drive such a conformational change of polypeptides. © 2009 American Chemical Society.
DOI
10.1021/ma900341m
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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