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Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex - a new promising X-ray contrast agent

Title
Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex - a new promising X-ray contrast agent
Authors
Krasilnikova, Anna A.Solovieva, Anastasiya O.Trifonova, Kristina E.Brylev, Konstantin A.Ivanov, Anton A.Kim, Sung-JinShestopalov, Michael A.Fufaeva, Maria S.Shestopalov, Alexander M.Mironov, Yuri V.Poveshchenko, Alexander F.Shestopalova, Lidia V.
Ewha Authors
김성진
SCOPUS Author ID
김성진scopus
Issue Date
2016
Journal Title
Contrast Media & Molecular Imaging
ISSN
1555-4309JCR Link1555-4317JCR Link
Citation
vol. 11, no. 6, pp. 459 - 466
Keywords
octahedral rhenium cluster complexvascular contrast agentcellular internalizationacute intravenous toxicitydrug developmentsafety assessment
Publisher
WILEY-BLACKWELL
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The octahedral cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)(2))(6)] has been shown to be highly radio dense, thus becoming a promising X-ray contrast agent. It was also shown that this compound had low cytotoxic effect in vitro, low acute toxicity in vivo and was eliminated rapidly from the body through the urinary tract. The present contribution describes a more detailed cellular internalization assay and morphological analysis after intravenous injection of this hexarhenium cluster compound at different doses. The median lethal dose (LD50) of intravenously administrated compound was calculated (4.67 +/- 0.69g/kg). Results of the study clearly indicated that the cluster complex H-n[{Re6Se8}(P(C2H4CONH2)(C2H4COO)(2))(6)](n-10) was not internalized into cells in vitro and induced only moderate morphological alterations of kidneys at high doses without any changes in morphology of liver, spleen, duodenum, or heart of mice. Copyright (c) 2016 John Wiley & Sons, Ltd.
DOI
10.1002/cmmi.1707
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자연과학대학 > 화학·나노과학전공 > Journal papers
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