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Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex - a new promising X-ray contrast agent
- Title
- Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex - a new promising X-ray contrast agent
- Authors
- Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Trifonova, Kristina E.; Brylev, Konstantin A.; Ivanov, Anton A.; Kim, Sung-Jin; Shestopalov, Michael A.; Fufaeva, Maria S.; Shestopalov, Alexander M.; Mironov, Yuri V.; Poveshchenko, Alexander F.; Shestopalova, Lidia V.
- Ewha Authors
- 김성진
- SCOPUS Author ID
- 김성진
- Issue Date
- 2016
- Journal Title
- Contrast Media & Molecular Imaging
- ISSN
- 1555-4309
1555-4317
- Citation
- Contrast Media & Molecular Imaging vol. 11, no. 6, pp. 459 - 466
- Keywords
- octahedral rhenium cluster complex; vascular contrast agent; cellular internalization; acute intravenous toxicity; drug development; safety assessment
- Publisher
- WILEY-BLACKWELL
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The octahedral cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)(2))(6)] has been shown to be highly radio dense, thus becoming a promising X-ray contrast agent. It was also shown that this compound had low cytotoxic effect in vitro, low acute toxicity in vivo and was eliminated rapidly from the body through the urinary tract. The present contribution describes a more detailed cellular internalization assay and morphological analysis after intravenous injection of this hexarhenium cluster compound at different doses. The median lethal dose (LD50) of intravenously administrated compound was calculated (4.67 +/- 0.69g/kg). Results of the study clearly indicated that the cluster complex H-n[{Re6Se8}(P(C2H4CONH2)(C2H4COO)(2))(6)](n-10) was not internalized into cells in vitro and induced only moderate morphological alterations of kidneys at high doses without any changes in morphology of liver, spleen, duodenum, or heart of mice. Copyright (c) 2016 John Wiley & Sons, Ltd.
- DOI
- 10.1002/cmmi.1707
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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