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Catalytic Formation of Hydrogen Peroxide from Coenzyme NADH and Dioxygen with a Water-Soluble Iridium Complex and a Ubiquinone Coenzyme Analogue

Title
Catalytic Formation of Hydrogen Peroxide from Coenzyme NADH and Dioxygen with a Water-Soluble Iridium Complex and a Ubiquinone Coenzyme Analogue
Authors
Suenobu, TomoyoshiShibata, SatoshiFukuzumi, Shunichi
Ewha Authors
Shunichi Fukuzumi
SCOPUS Author ID
Shunichi Fukuzumiscopus
Issue Date
2016
Journal Title
INORGANIC CHEMISTRY
ISSN
0020-1669JCR Link1520-510XJCR Link
Citation
vol. 55, no. 15, pp. 7747 - 7754
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A ubiquinone coenzyme analogue (Q(0): 2,3-dimethoxy-5-methyl-1,4-benzoquinone) was reduced by coenzyme NADH to yield the corresponding reduced form of Q(0) (Q(0)H(2)) in the presence of a catalytic amount of a [C,N] cyclometalated organoiridium complex (1: [Ir-III(Cp*)(4-(1H-pyrazol-1-yl-kappa N-2)benzoic acid-kappa C-3)(H2O)](2)SO4) in water at ambient temperature as observed in the respiratory chain complex I (Complex I). In the catalytic cycle, the reduction of 1 by NADH produces the corresponding iridium hydride complex that in turn reduces Q(0) to produce Q(0)H(2). Q(0)H(2) reduced dioxygen to yield hydrogen peroxide (H2O2) under slightly basic conditions. Catalytic generation of H2O2 was made possible in the reaction of O-2 with NADH as the functional expression of NADH oxidase in white blood cells utilizing the redox cycle of Q(0) as well as 1 for the first time in a nonenzymatic homogeneous reaction system.
DOI
10.1021/acs.inorgchem.6b01220
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자연과학대학 > 화학·나노과학전공 > Journal papers
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