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Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity
- Title
- Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity
- Authors
- Yeon, Jeong-Tae; Kim, Hiyoung; Kim, Kwang-Jin; Lee, Jihye; Won, Dong Hwan; Nam, Sang-Jip; Kim, Seong Hwan; Kang, Heonjoong; Son, Young-Jin
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2016
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- ISSN
- 0163-3864
1520-6025
- Citation
- JOURNAL OF NATURAL PRODUCTS vol. 79, no. 7, pp. 1730 - 1736
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP(+)-MNCs in a dose-dependent manner without any cytotoxicity up to 10 mu M. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.
- DOI
- 10.1021/acs.jnatprod.6b00004
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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