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Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity

Title
Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity
Authors
Yeon, Jeong-TaeKim, HiyoungKim, Kwang-JinLee, JihyeWon, Dong HwanNam, Sang-JipKim, Seong HwanKang, HeonjoongSon, Young-Jin
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2016
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 79, no. 7, pp. 1730 - 1736
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP(+)-MNCs in a dose-dependent manner without any cytotoxicity up to 10 mu M. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.
DOI
10.1021/acs.jnatprod.6b00004
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자연과학대학 > 화학·나노과학전공 > Journal papers
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