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ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion

Title
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
Authors
Jung, Seung HeeYoo, Eun HyeYu, Mi JinSong, Hyeon MyeongKang, Hee YoonCho, Je-YoelLee, Jong Ran
Ewha Authors
이종란
SCOPUS Author ID
이종란scopus
Issue Date
2016
Journal Title
JOURNAL OF IMMUNOLOGY
ISSN
0022-1767JCR Link1550-6606JCR Link
Citation
vol. 197, no. 3, pp. 942 - 952
Publisher
AMER ASSOC IMMUNOLOGISTS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A novel adaptor protein was identified by analyzing phosphotyrosine proteomes from membrane rafts of activated T cells. This protein showed sequence similarity to a well-known T cell adaptor protein, adhesion and degranulation-promoting adaptor protein (ADAP); therefore, the novel protein was designated activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP). Suppression of ARAP impaired the major signaling pathways downstream of the TCR. ARAP associated with the Src homology 2 domain of Src homology 2-containing leukocyte protein of 76 kDa via the phosphorylation of two YDDV motifs in response to TCR stimulation. ARAP also mediated integrin activation but was not involved in actin polymerization. The results of this study indicate that a novel T cell adaptor protein, ARAP, plays a unique role in T cells as a part of both the proximal activation signaling and inside-out signaling pathways that result in integrin activation and T cell adhesion.
DOI
10.4049/jimmunol.1501913
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자연과학대학 > 생명과학전공 > Journal papers
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