DSpace at EWHA: Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template

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DC Field	Value	Language
dc.contributor.author	최선	*
dc.date.accessioned	2016-08-29T12:08:40Z	-
dc.date.available	2016-08-29T12:08:40Z	-
dc.date.issued	2016	*
dc.identifier.issn	0960-894X	*
dc.identifier.issn	1464-3405	*
dc.identifier.other	OAK-19080	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/231766	-
dc.description.abstract	A series of homologous analogues of prototype antagonist 1 and its urea surrogate were investigated as hTRPV1 ligands. Through one-carbon elongation in the respective pharmacophoric regions, N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea was identified as a novel and potent TRPV1 antagonistic template. Its representative compound 27 showed a potency comparable to that of lead compound 1. Docking analysis of compound 27 in our hTRPV1 homology model indicated that its binding mode was similar with that of 1S. (C) 2016 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD	*
dc.subject	Vanilloid receptor 1	*
dc.subject	TRPV1 antagonists	*
dc.subject	Analgesic	*
dc.title	Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template	*
dc.type	Article	*
dc.relation.issue	15	*
dc.relation.volume	26	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3603	*
dc.relation.lastpage	3607	*
dc.relation.journaltitle	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS	*
dc.identifier.doi	10.1016/j.bmcl.2016.06.010	*
dc.identifier.wosid	WOS:000380574100042	*
dc.identifier.scopusid	2-s2.0-84978878151	*
dc.author.google	Ann, Jihyae	*
dc.author.google	Sun, Wei	*
dc.author.google	Zhou, Xing	*
dc.author.google	Jung, Aeran	*
dc.author.google	Baek, Jisoo	*
dc.author.google	Lee, Sunho	*
dc.author.google	Kim, Changhoon	*
dc.author.google	Yoon, Suyoung	*
dc.author.google	Hong, Sunhye	*
dc.author.google	Choi, Sun	*
dc.author.google	Turcios, Noe A.	*
dc.author.google	Herold, Brienna K. A.	*
dc.author.google	Esch, Timothy E.	*
dc.author.google	Lewin, Nancy E.	*
dc.author.google	Abramovitz, Adelle	*
dc.author.google	Pearce, Larry V.	*
dc.author.google	Blumberg, Peter M.	*
dc.author.google	Lee, Jeewoo	*
dc.contributor.scopusid	최선(8659831000)	*
dc.date.modifydate	20240305081003	*