Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재상 | * |
dc.date.accessioned | 2016-08-29T12:08:00Z | - |
dc.date.available | 2016-08-29T12:08:00Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 2093-596X | * |
dc.identifier.other | OAK-18953 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231684 | - |
dc.description.abstract | Background: Melanocortin-1 receptor (Mc1r), a key signaling receptor for melanogenesis, has been reported to mediate migration of B16F10 melanoma cells. Interestingly, this activity appears to be a part of the constitutive signaling of Mc1r. Methods: We carried out small interfering RNA-mediated knock-down of Mc1r on murine melanoma B16F10 cells and performed microarray analysis to characterize changes in the gene expression profile. Results: We isolated 22 and four genes whose expression decreased and increased, respectively, by 2.5-fold or higher as the result of Mc1r knock-down. Several down-regulated genes have been proposed to be involved in cell migration. Among these genes are several members of the chemokine gene family. Conclusion: We provide a gene set for further functional analyses of Mc1r. The Mc1r target genes we present may be particularly relevant for understanding the ligand-independent activity of Mc1r. Further examination of the mode of action may lead to novel strategies in regulating the migration and metastasis of melanoma cells. © 2014 Korean Endocrine Society. | * |
dc.language | English | * |
dc.publisher | Korean Endocrine Society | * |
dc.subject | Chemokines | * |
dc.subject | Melanocortin | * |
dc.subject | Melanoma | * |
dc.subject | Migration | * |
dc.subject | Receptor | * |
dc.subject | Type 1 | * |
dc.title | Gene expression regulation by agonist-independent constitutive signaling of Melanocortin-1 receptor | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 179 | * |
dc.relation.lastpage | 184 | * |
dc.relation.journaltitle | Endocrinology and Metabolism | * |
dc.identifier.doi | 10.3803/EnM.2014.29.2.179 | * |
dc.identifier.scopusid | 2-s2.0-84975687486 | * |
dc.author.google | Seong I. | * |
dc.author.google | Kim J. | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.date.modifydate | 20231120151223 | * |