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SoxD transcription factors: Multifaceted players of neural development

Title
SoxD transcription factors: Multifaceted players of neural development
Authors
Ji E.H.Kim J.
Ewha Authors
김재상
SCOPUS Author ID
김재상scopus
Issue Date
2016
Journal Title
International Journal of Stem Cells
ISSN
2005-3606JCR Link
Citation
vol. 9, no. 1, pp. 3 - 8
Keywords
Neural developmentNeural stem cellSox13Sox5Sox6SoxD
Publisher
Sungkyunkwan University
Indexed
SCOPUS scopus
Abstract
SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter- specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.
DOI
10.15283/ijsc.2016.9.1.3
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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