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In hot pursuit of the first vaccine against respiratory syncytial virus

Title
In hot pursuit of the first vaccine against respiratory syncytial virus
Authors
Kim J.Y.Chang J.
Ewha Authors
장준김주영
SCOPUS Author ID
장준scopus; 김주영scopus
Issue Date
2016
Journal Title
Yonsei Medical Journal
ISSN
0513-5796JCR Link
Citation
vol. 57, no. 4, pp. 809 - 816
Keywords
ImmunityRespiratory syncytial virusesVaccineVaccine-enhanced diseases
Publisher
Yonsei University College of Medicine
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Human respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infection, such as bronchiolitis, bronchitis, or pneumonia, in both infants and the elderly. Despite the global burden of diseases attributable to RSV infection, no clinically approved vaccine is available, and a humanized monoclonal antibody for prophylaxis is not readily affordable in developing countries. There are several hurdles to the successful development of RSV vaccines: immune-vulnerable target populations such as premature infants, pregnant women, and immunocompromised people; safety concerns associated with vaccine-enhanced diseases; repeated infection; and waning memory. To develop successful strategies for the prevention of RSV infection, it is necessary to understand the protective and pathologic roles of host immune responses to RSV infection. In this review, we will summarize the positive and negative relationship between RSV infection and host immunity and discuss strategies for the development of the first successful RSV vaccine. © Yonsei University College of Medicine 2016.
DOI
10.3349/ymj.2016.57.4.809
Appears in Collections:
약학대학 > 약학과 > Journal papers
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