Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 오구택 | * |
dc.contributor.author | 김현석 | * |
dc.contributor.author | 허정은 | * |
dc.date.accessioned | 2016-08-29T12:08:51Z | - |
dc.date.available | 2016-08-29T12:08:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-18694 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231584 | - |
dc.description.abstract | Global deletion of the gene encoding a nuclear histone deacetylase sirtuin 6 (Sirt6) in mice leads to osteopenia with a low bone turnover due to impaired bone formation. But whether Sirt6 regulates osteoclast differentiation is less clear. Here we show that Sirt6 functions as a transcriptional regulator to directly repress anti-osteoclastogenic gene expression. Targeted ablation of Sirt6 in hematopoietic cells including osteoclast precursors resulted in increased bone volume caused by a decreased number of osteoclasts. Overexpression of Sirt6 led to an increase in osteoclast formation, and Sirt6-deficient osteoclast precursor cells did not undergo osteoclast differentiation efficiently. Moreover, we showed that Sirt6, induced by RANKL-dependent NFATc1 expression, forms a complex with B lymphocyte-induced maturation protein-1 (Blimp1) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb. These findings identify Sirt6 as a novel regulator of osteoclastogenesis by acting as a transcriptional repressor. | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation | * |
dc.type | Article | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/srep26186 | * |
dc.identifier.wosid | WOS:000375993700001 | * |
dc.identifier.scopusid | 2-s2.0-84971216466 | * |
dc.author.google | Park S.J. | * |
dc.author.google | Huh J.-E. | * |
dc.author.google | Shin J. | * |
dc.author.google | Park D.R. | * |
dc.author.google | Ko R. | * |
dc.author.google | Jin G.-R. | * |
dc.author.google | Seo D.-H. | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Shin H.-I. | * |
dc.author.google | Oh G.T. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 김현석(57191717681) | * |
dc.contributor.scopusid | 허정은(57220704929) | * |
dc.date.modifydate | 20240415140424 | * |