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Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway

Title
Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway
Authors
Le T.C.Yang I.Yoon Y.J.Nam S.-J.Fenical W.
Ewha Authors
윤여준남상집
SCOPUS Author ID
윤여준scopus; 남상집scopus
Issue Date
2016
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 18, no. 9, pp. 2256 - 2259
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid. © 2016 American Chemical Society.
DOI
10.1021/acs.orglett.6b00892
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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