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Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea
- Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea
- Lamichhane, Dirga Kumar; Leem, Jong-Han; Kim, Hwan-Cheol; Lee, Ji-Young; Park, Myung-Sook; Jung, Dal-Young; Ko, Jung Keun; Ha, Mina; Kim, Yangho; Hong, Yun-Chul; Ha, Eun-Hee
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- PUBLIC HEALTH NUTRITION
- 1368-9800; 1475-2727
- vol. 19, no. 14, pp. 2562 - 2571
- Biomarker; Children; Polycyclic aromatic hydrocarbons; PAH-rich meat; Pregnancy; Birth weight
- CAMBRIDGE UNIV PRESS
- SCIE; SCOPUS
- Objective: Polycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes. Design: Prospective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from chronic disease such as diabetes and hypertension, were included in the study. Maternal consumption of PAH-rich meat was estimated through FFQ. Multiple linear regression was used to assess factors related to higher intake and the association between dietary PAH and birth outcomes. Setting: Republic of Korea, 2006-2011. Subjects: Pregnant women (n 778) at 12-28 weeks of gestation enrolled in the Mothers and Children's Environmental Health (MOCEH) study. Results: The multivariable regression model showed a significant reduction in birth weight associated with higher consumption level of foods rich in PAH, such as grilled or roasted meat, during pregnancy (beta-17.48 g, P < 0.05 for every 1 point higher in meat score). Further adjusting for biomarkers of airborne PAH did not alter this association. There was no evidence that higher consumption level of PAH-rich meat shortens the duration of gestation (P = 0.561). Regression models performed for birth length and head circumference produced negative effects that were not statistically significant. Conclusions: Consumption of higher levels of barbecued, fried, roasted and smoked meats during pregnancy was associated with reduced birth weight. Dietary risk of PAH exposure in Korean women is of concern.
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