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Mechanism-based management for mucositis: Option for treating side effects without compromising the efficacy of cancer therapy

Title
Mechanism-based management for mucositis: Option for treating side effects without compromising the efficacy of cancer therapy
Authors
Kwon Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2016
Journal Title
OncoTargets and Therapy
ISSN
1178-6930JCR Link
Citation
vol. 9, pp. 2007 - 2016
Keywords
ApoptosisChemotherapyCytokineMucositisRadiotherapyReactive oxygen species
Publisher
Dove Medical Press Ltd.
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Mucositis is a major side effect induced by chemotherapy and radiotherapy. Although mucositis is a leading cause of morbidity and mortality in cancer patients, management is largely limited to controlling symptoms, and few therapeutic agents are available for treatment. Since mucositis could be inhibited by the modulation of radiotherapy- or chemotherapy-induced pathways independently of cancer treatment, there is an opportunity for the development of more targeted therapies and interventions. This article examined potential therapeutic agents that have been investigated for the prevention and/or inhibition of mucositis induced by conventional chemotherapy and radiotherapy. They can be classified according to their mechanisms of action: scavenging reactive oxygen species, inhibition of specific cytokine production or inflammation, and inhibition of apoptosis. These early events may be good target pathways for preventing the pathogenesis of mucositis. Considering that both cancer therapy and therapeutic agents for mucositis act on both normal and cancer cells, agents that inhibit mucositis should act through mechanisms that selectively protect normal cells without compromising cancer treatment. Therefore, mechanism-based guidance for the treatment of mucositis is critical to prevent risky treatments for cancer patients and to relieve detrimental side effects effectively from cancer ther © 2016 Shen et al.
DOI
10.2147/OTT.S96899
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엘텍공과대학 > 식품공학전공 > Journal papers
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