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Development of A3 adenosine receptor ligands.
- Development of A3 adenosine receptor ligands.
- Jeong L.S.
- Ewha Authors
- Issue Date
- Journal Title
- Nucleic acids symposium series (2004)
- no. 52, pp. 79 - 80
- 4'-Thioadenosines have been discovered as novel templates for A(3) adenosine ligands. Among these, 4'-thioadenosine-5'-monoalkyluronamides were discovered as novel potent and selective A(3) adenosine receptor agonists, while 4'-thioadenosine-5'-dialkyluronamides and truncated 4'-thioadenosine derivatives exhibited potent and selective antagonism at the A(3) adenosine receptor.
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