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Enhanced prodiginines production in Streptomyces coelicolor M511 by stress of acidic pH shock

Title
Enhanced prodiginines production in Streptomyces coelicolor M511 by stress of acidic pH shock
Authors
Mo S.
Ewha Authors
모상준
Issue Date
2010
Journal Title
Korean Journal of Microbiology and Biotechnology
ISSN
1598-642XJCR Link
Citation
vol. 38, no. 3, pp. 273 - 277
Indexed
SCOPUS; KCI scopus
Abstract
Undecylprodiginine and streptorubin B are red-pigmented antibiotics produced by Streptomyces coelicolor A3(2). In this study, we investigated the correlation between productivity of these red-pigmented antibiotics and stress of pH shock. Biosynthesis of these red-pigmented antibiotics is enhanced at acidic pH shock on solid R2YE medium. The optimal pH shock is pH 4 which led to 1.6 fold and two-fold increase in the production of undecylprodiginine and streptorubin B as compared with control, respectively. In addition, the extract of pH 4 shocked cells exhibited a remarkable activity against Trichophyton mentagrophytes. However, neutral and basic pH shock did not give raise to promote a production of these red-pigmented antibiotics as well as antifungal activity. Thus, although the acidic pH shock is simple and easy method, it should be extremely effective approach to enhance a productivity of these red-pigmented antibiotics and other secondary metabolites.
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연구기관 > 나노·바이오기술연구소 > Journal papers
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