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Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines

Title
Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines
Authors
Kadayat T.M.Park S.Jun K.-Y.Magar T.B.T.Bist G.Shrestha A.Na Y.Kwon Y.Lee E.-S.
Ewha Authors
권영주전규연
SCOPUS Author ID
권영주scopus
Issue Date
2016
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 26, no. 7, pp. 1726 - 1731
Keywords
2,4-Diphenyl-5H-indeno[1,2-b]pyridine analogAnticancer agentsBreast cancerCytotoxicity
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In continuation of our previous work, six hydroxylated 2,4-diphenyl-5H-indeno[1,2-b]pyridine analogs were modified by introducing one chlorine functionality at ortho, meta or para position of the 2- or 4-phenyl ring. Eighteen new chlorinated compounds were thus prepared and assessed for topoisomerase inhibitory activity and cytotoxicity against HCT15, T47D, and HeLa cancer cell lines. All of the chlorinated compounds displayed significant cytotoxic effect, revealing potent anticancer activity against T47D breast cancer cells. This functional group modification allowed us to explore the importance of chlorine group substitution for the cytotoxic properties. The information reported here provides valuable insight for further study to develop new anticancer agents using related scaffolds. © 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2016.02.053
Appears in Collections:
약학대학 > 약학과 > Journal papers
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