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Drug-clay nanohybrids as sustained delivery systems

Title
Drug-clay nanohybrids as sustained delivery systems
Authors
Yang, Jae-HunLee, Ji-HeeRyu, Hyeon-JuElzatahry, Ahmed A.Alothman, Zeid A.Choy, Jin-Ho
Ewha Authors
최진호양재훈
SCOPUS Author ID
최진호scopus; 양재훈scopus
Issue Date
2016
Journal Title
APPLIED CLAY SCIENCE
ISSN
0169-1317JCR Link1872-9053JCR Link
Citation
vol. 130, pp. 20 - 32
Keywords
ClayDrug delivery carrierControlled and sustained releaseNanohybrid
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Biocompatible 2-dimensional layered compounds such as clays and layered double hydroxides (anionic clays) have been explored and utilized in drug delivery system for therapeutic application because they can safely encapsulate drug molecules via intercalation reaction. Therefore, various kinds of drug molecules and bio-functional molecules with cationic or anionic charge have been incorporated into clay delivery carriers, giving rise to the heterostructured layered nanohybrids with chemo-therapeutic and gene-therapeutic functions. Recently, such inorganic delivery systems have received growing attention because their inertness and low toxicity gives rise to safety and stability in bio-systems. Furthermore, the hybridization of drug with clays offers the fascinating features such as controlled and sustained release, improved water-solubility, and even protective and targeted delivery. Unique release behaviors of drugs from the drug-clay nanohybrids are originated from molecular level incorporation, and strong interaction between drug and inorganic layers including electrostatic and hydrogen bonding interactions. In the present review, various drug-clay nanohybrids will be introduced, and their recent development will be highlighted in the viewpoint of oral administration drugs with controlled and sustained release. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.clay.2016.01.021
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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