Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-29T12:08:45Z | - |
dc.date.available | 2016-08-29T12:08:45Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0955-3002 | * |
dc.identifier.other | OAK-16151 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230934 | - |
dc.description.abstract | Purpose: We investigated the effects of whole-body exposure to the 915 MHz radiofrequency identification (RFID) on mela-tonin biosynthesis and the activity of rat pineal arylalkylamine N-acetyltransferase (AANAT).Materials and methods: Rats were exposed to RFID (whole-body specific absorption rate, 4 W/kg) for 8 h/day, 5 days/week, for weeks during the nighttime. Total volume of urine excreted during a 24-h period was collected after RFID exposure. Uri-nary melatonin and 6-hydroxymelatonin sulfate (6-OHMS) was measured by gas chromatography-mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA), respectively. AANAT enzyme activity was measured using liquid biphasic dif-13 fusion assay. Protein levels and mRNA expression of AANAT was 14 measured by Western blot and reverse transcription polymerase 15 chain reaction (RT-PCR) analysis, respectively.Results: Eight hours of nocturnal RFID exposure caused a sig-nificant reduction in both urinary melatonin (p = 0. 003) and 6-OHMS (p = 0. 026). Activity, protein levels, and mRNA expres-sion of AANAT were suppressed by exposure to RFID (p < 0. 05).Conclusions: Our results suggest that nocturnal RFID exposure can cause reductions in the levels of both urinary melatonin and 6-OHMS, possibly due to decreased melatonin biosynthesis via suppression of Aanat gene transcription in the rat pineal gland. © 2015 Informa UK, Ltd. | * |
dc.language | English | * |
dc.publisher | Taylor and Francis Ltd | * |
dc.subject | Melatonin | * |
dc.subject | Pineal gland | * |
dc.subject | Radiofrequency identifi cation | * |
dc.subject | Rat | * |
dc.title | Eight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male rats | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 898 | * |
dc.relation.lastpage | 907 | * |
dc.relation.journaltitle | International Journal of Radiation Biology | * |
dc.identifier.doi | 10.3109/09553002.2015.1075075 | * |
dc.identifier.wosid | WOS:000366835600006 | * |
dc.identifier.scopusid | 2-s2.0-84951273572 | * |
dc.author.google | Sun Kim H. | * |
dc.author.google | Paik M.-J. | * |
dc.author.google | Hee Lee Y. | * |
dc.author.google | Lee Y.-S. | * |
dc.author.google | Do Choi H. | * |
dc.author.google | Pack J.-K. | * |
dc.author.google | Kim N. | * |
dc.author.google | Ahn Y.H. | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |