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Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production

Title
Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production
Authors
Choi E.J.Nam S.-J.Paul L.Beatty D.Kauffman C.A.Jensen P.R.Fenical W.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2015
Journal Title
Chemistry and Biology
ISSN
1074-5521JCR Link
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
Low-nutrient media and long incubation times facilitated the cultivation of 20 taxonomically diverse Gram-negative marine bacteria within the phyla Bacteroidetes and Proteobacteria. These strains comprise as many as three new families and include members of clades that had only been observed using culture-independent techniques. Chemical studies of the type strains representing two new families within the order Cytophagales led to the isolation of nine new alkaloid secondary metabolites that can be grouped into four distinct structure classes, including azepinones, aziridines, quinolones, and pyrazinones. Several of these compounds possess antibacterial properties and appear, on structural grounds, to be produced by amino acid-based biosynthetic pathways. Our results demonstrate that relatively simple cultivation techniques can lead to the isolation of new bacterial taxa that are capable of the production of alkaloid secondary metabolites with antibacterial activities. These findings support continued investment in cultivation techniques as a method for natural product discovery. Choi etal. illustrate that low-nutrient media and long incubation times lead to the isolation of rare, previously uncultured marine bacteria that produce new antibacterial metabolites. Their work demonstrates that unique marine bacteria are easier to cultivate than previously suggested. © 2015 Elsevier Ltd.
DOI
10.1016/j.chembiol.2015.07.014
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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