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The inhibitory effect of alisol A 24-acetate from alisma canaliculatum on osteoclastogenesis

Title
The inhibitory effect of alisol A 24-acetate from alisma canaliculatum on osteoclastogenesis
Authors
Kim K.-J.Leutou A.S.Yeon J.-T.Choi S.-W.Kim S.H.Yee S.-T.Choi K.H.Nam S.-J.Son Y.-J.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2015
Journal Title
International Journal of Endocrinology
ISSN
1687-8337JCR Link
Citation
vol. 2015
Publisher
Hindawi Publishing Corporation
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Osteoporosis is a disease that decreases bone mass. The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs. Osteoporosis treatment is all-important in preventing bone loss. One strategy for osteoporosis treatment is to inhibit osteoclastogenesis. Osteoclasts are bone-resorbing multinucleated cells, and overactive osteoclasts and/or their increased number are observed in bone disorders including osteoporosis and rheumatoid arthritis. Bioactivity-guided fractionations led to the isolation of alisol A 24-acetate from the dried tuber of Alisma canaliculatum. Alisol A 24-acetate inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1, which plays an essential role in osteoclast differentiation. Furthermore, it inhibited the expression of DC-STAMP and cathepsin K, which are related to cell-cell fusion of osteoclasts and bone resorption, respectively. Therefore, alisol A 24-acetate could be developed as a new structural scaffold for inhibitors of osteoclast differentiation in order to develop new drugs against osteoporosis. © 2015 Kwang-Jin Kim et al.
DOI
10.1155/2015/132436
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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