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The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean

Title
The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean
Authors
Lee, AnbokWoo, JuhyunPark, HeejungSung, Sun HeeSeoh, Ju-YoungLim, WoosungMoon, Byung-In
Ewha Authors
서주영성순희문병인임우성박희정우주현
SCOPUS Author ID
서주영scopus; 성순희scopus; 문병인scopus; 임우성scopus; 우주현scopus
Issue Date
2016
Journal Title
BREAST CANCER
ISSN
1340-6868JCR Link1880-4233JCR Link
Citation
vol. 23, no. 5, pp. 685 - 691
Keywords
YBX1 proteinHumanCytoplasmPrognosisBreast neoplasm
Publisher
SPRINGER JAPAN KK
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer. Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed. Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (aeyen14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043). This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.
DOI
10.1007/s12282-015-0625-8
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의학전문대학원 > 의학과 > Journal papers
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