Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서주영 | * |
dc.contributor.author | 성순희 | * |
dc.contributor.author | 문병인 | * |
dc.contributor.author | 임우성 | * |
dc.contributor.author | 박희정 | * |
dc.contributor.author | 우주현 | * |
dc.date.accessioned | 2016-08-29T12:08:20Z | - |
dc.date.available | 2016-08-29T12:08:20Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1340-6868 | * |
dc.identifier.issn | 1880-4233 | * |
dc.identifier.other | OAK-15328 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230714 | - |
dc.description.abstract | The human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer. Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed. Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (aeyen14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043). This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer. | * |
dc.language | English | * |
dc.publisher | SPRINGER JAPAN KK | * |
dc.subject | YBX1 protein | * |
dc.subject | Human | * |
dc.subject | Cytoplasm | * |
dc.subject | Prognosis | * |
dc.subject | Breast neoplasm | * |
dc.title | The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 685 | * |
dc.relation.lastpage | 691 | * |
dc.relation.journaltitle | BREAST CANCER | * |
dc.identifier.doi | 10.1007/s12282-015-0625-8 | * |
dc.identifier.wosid | WOS:000382436800001 | * |
dc.identifier.scopusid | 2-s2.0-84937597188 | * |
dc.author.google | Lee, Anbok | * |
dc.author.google | Woo, Juhyun | * |
dc.author.google | Park, Heejung | * |
dc.author.google | Sung, Sun Hee | * |
dc.author.google | Seoh, Ju-Young | * |
dc.author.google | Lim, Woosung | * |
dc.author.google | Moon, Byung-In | * |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | * |
dc.contributor.scopusid | 성순희(7202731948;58455037400) | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 임우성(27167744500) | * |
dc.contributor.scopusid | 박희정(56085778500) | * |
dc.contributor.scopusid | 우주현(56211277800) | * |
dc.date.modifydate | 20240318132538 | * |