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Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients

Title
Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients
Authors
Choi Y.Lee I.J.Lee C.Y.Cho J.H.Choi W.H.Yoon H.I.Lee Y.-H.Lee C.G.Keum K.C.Chung K.Y.Haam S.J.Paik H.C.Lee K.K.Moon S.R.Lee J.-Y.Park K.-R.Kim Y.S.
Ewha Authors
박경란
SCOPUS Author ID
박경란scopus
Issue Date
2015
Journal Title
Radiation Oncology Journal
ISSN
2234-1900JCR Link
Citation
vol. 33, no. 2, pp. 75 - 82
Keywords
Adjuvant radiotherapyNon-small cell lung cancerPrognostic factor
Publisher
Department of Radiation Oncology
Indexed
SCOPUS scopus
Abstract
Purpose: We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC). Materials and Methods: T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of invasion: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor <2 cm distal to the carina, and tumor-associated collapse. Results: The median overall survival (OS) and disease-free survival (DFS) were 55.3 months and 51.2 months, respectively. In postoperative T3N0M0 patients, the tumor size was a significant prognostic factor for survival (OS, p = 0.035 and DFS, p = 0.035, respectively). Patients with endobronchial tumors within 2 cm of the carina also showed better OS and DFS than those in the other T3 subtypes (p = 0.018 and p = 0.016, respectively). However, adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Only patients with mediastinal pleural invasion (n = 25) demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively). Conclusion: The T3N0 NSCLC subtype that showed the most favorable prognosis is the one with endobronchial tumors within 2 cm of the carina. Adjuvant radiotherapy is not effective in improving survival outcome in resected T3N0 NSCLC. © 2015. The Korean Society for Radiation Oncology.
DOI
10.3857/roj.2015.33.2.75
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의료원 > 의료원 > Journal papers
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