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Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial
- Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial
- Kim H.G.; Huh K.C.; Koo H.S.; Kim S.-E.; Kim J.-O.; Kim T.I.; Kim H.-S.; Myung S.-J.; Park D.I.; Shin J.E.; Yang D.-H.; Lee S.-H.; Lee J.S.; Lee C.K.; Chang D.K.; Joo Y.-E.; Cha J.M.; Hong S.P.; Kim H.J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Gut and Liver
- vol. 9, no. 4, pp. 494 - 501
- Bowel preparation; Colonoscopy; Polyethylene glycols; Sodium picosulfate with magnesium citrate
- Joe Bok Chung
- SCIE; SCOPUS; KCI
- Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety. © This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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