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An Open-label Comparison of a New Generic Sevoflurane Formulation with Original Sevoflurane in Patients Scheduled for Elective Surgery under General Anesthesia

Title
An Open-label Comparison of a New Generic Sevoflurane Formulation with Original Sevoflurane in Patients Scheduled for Elective Surgery under General Anesthesia
Authors
Byon H.-J.Choi B.-M.Bang J.-Y.Lee E.-K.Lee S.-S.Noh G.-J.
Ewha Authors
이은경
SCOPUS Author ID
이은경scopus
Issue Date
2015
Journal Title
Clinical Therapeutics
ISSN
1492-2918JCR Link
Citation
vol. 37, no. 4, pp. 887 - 901
Keywords
compound Aeffectivenessgeneric sevofluraneinorganic fluoride
Publisher
Excerpta Medica Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose To compare the stability, effectiveness, and safety profiles of a new generic sevoflurane with those of the original sevoflurane formulation in patients undergoing elective surgery. Methods An accelerated 3-month storage test was performed to evaluate the compositional changes in generic sevoflurane stored in glass bottles. In addition, 182 patients were randomly allocated to receive generic (n = 89 [54 men and 35 women]; mean [SD] age, 49.9 [11.6] years) or original (n = 93 [61 men and 32 women]; mean [SD] age, 49.6 [11.1] years) sevoflurane at a gas flow of 3 L/min for approximately 3 hours. The mean minimum alveolar concentration (MAC) during sevoflurane anesthesia was evaluated, and gas samples for measuring compound A were collected from the inspiratory limb of the circuit at preset intervals. Blood samples for measuring serum inorganic fluoride were obtained at preset intervals (pharmacokinetic group: generic/original sevoflurane = 45/46). Renal biomarkers, such as N-acetyl-β-glucosaminidase, α- and π-glutathione-S-transferase, albumin, urine protein and osmolality, serum creatinine and osmolality, creatinine clearance, and blood urea nitrogen, were measured at preset intervals (renal biomarker group: generic/original sevoflurane = 44/47). Adverse reactions were monitored for 72 hours after discontinuation of sevoflurane use. Findings Generic sevoflurane contained in glass bottles was stable for 3 months. The mean MAC was similar for generic and original sevoflurane (median [range], 0.93 [0.67-1.29] vs 0.94 [0.63-1.5] vol%). Adverse event rates were similar (90.3% vs 84.3%), as were the AUC<inf>last</inf> of inorganic fluoride (333.7 [112.7-1264.7] vs 311.9 [81.5-1266.5] hours·μmol/L) and compound A (51.8 [6.3-204.5] vs 55.3 [10.8-270.6] hours·ppm). Biomarkers associated with renal injury were not significantly different between the 2 formulations. Implications No significant difference was found in the mean MAC between generic and original sevoflurane. ClinicalTrials.gov identifier: NCT01096212. © 2015 Elsevier HS Journals, Inc. All rights reserved.
DOI
10.1016/j.clinthera.2015.01.012
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자연과학대학 > 통계학전공 > Journal papers
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